Editorial. When in doubt, should we still cut it out?

Editorial Atherosclerosis Should We Stop TWEAKing It ?

Atherosclerosis is a very complex pathology. Over the past two decades we have come to appreciate that a major component of this pathological process is chronic inflammation. This inflammatory state is not only characterized by infiltration of lipid laden macrophages, the hallmark cell of this disease, into the vascular wall, but also is characterized by the infiltration of a host of other infl...

In spite of good results with 'inject and cut', should we scrutinize it? - yes, we should!

(2) Moreover, there is no agreement on and no international standardization of diagnostic criteria, which range from subjective macroscopic aspect, real and virtual chromoendoscopy and endomicroscopic methods up to optical biopsy and high-resolution endosonography [4] . (3) The same holds true for the definition and standardization of endoscopic techniques. Procedures such as polypectomy, EMR, ...

Performance of the “if in doubt, cut it out” rule for the management of nodular melanoma

BACKGROUND The recognition of nodular melanoma is clinically challenging, and the diagnostic accuracy of dermoscopy and confocal microscopy is lower than for superficial spreading melanoma. OBJECTIVES To test a management strategy consisting in the excision of any nodular lesion that cannot be confidently and precisely classified as a benign tumor after clinical and dermoscopic examination. ...

Erythema nodosum :what should we consider about it?

Microchimerism and Renal Transplantation: Doubt Still Persists

Background: The Presence of donor leukocytes in recipients of organ allograft has been shown even several years after transplantation. However, it remains unclear whether this donor cell microchimerism plays an effective role in allograft acceptance or is simply a consequence of immunosuppressive conditions in recipients. Objective: To study microchimerism in a group of kidney transplant recipi...